The powder's medicinal properties come from its bioactive compounds, primarily andrographolide. Historically and in traditional medicine systems, kalmegh has been used for:

Immune system support:  It is known for its immunity-boosting properties and is commonly used to fight off infections, colds, and fevers, including those associated with malaria and dengue.

Liver health: Kalmegh is a powerful liver tonic that helps protect and detoxify the organ. It stimulates bile flow, aids in the elimination of toxins, and helps manage liver issues such as jaundice, hepatitis, and fatty liver.

Digestive health: As a bitter laxative, it helps improve digestion, relieve indigestion, bloating, gas, and constipation by increasing the flow of digestive juices.

Anti-inflammatory effects: Its anti-inflammatory properties can help reduce swelling and pain associated with various inflammatory conditions, including joint pain and arthritis.

Respiratory health: It is traditionally used to alleviate respiratory issues like cough, cold, bronchitis, and sinusitis by acting as an expectorant to clear mucus.

Skin conditions: With its antibacterial and blood-purifying properties, kalmegh can be used to manage skin issues like acne, boils, and rashes.

Kalmegh powder is available as a stand-alone supplement or as an ingredient in herbal formulations and can be used in several ways. Due to its intense bitterness, it is often mixed with other substances to improve its palatability.

Common usage methods include:

Mixed with water or honey: For general health benefits, a small amount of powder (1–2 grams) is mixed with warm water, juice, or honey and consumed once or twice daily.

As a decoction: It can be prepared by boiling the dried leaves or powder in water for several minutes.

In capsules or tablets: These forms offer a more convenient way to consume kalmegh without the bitter taste.

While generally considered safe in moderation, certain precautions should be taken when using kalmegh powder:

Do not self-medicate: It is important to consult a healthcare professional before taking kalmegh, especially if you have pre-existing medical conditions.

Pregnancy and breastfeeding: Kalmegh can cause uterine contractions and may have anti-fertility effects. It should be avoided by pregnant or breastfeeding women.

Gastrointestinal issues: High doses may cause stomach upset, nausea, or diarrhea.

Blood pressure and sugar levels: Kalmegh can lower blood pressure and blood sugar, so it should be used with caution by people on medication for diabetes or hypotension.

Drug interactions: It can interact with certain medications, including blood thinners and immunosuppressants.